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"A surrogate endpoint used for accelerated approval is a marker – a laboratory measurement, radiographic image, physical sign or other measure that is thought to predict clinical benefit, but is not itself a measure of clinical benefit," according to the FDA. "Likewise, an intermediate clinical endpoint is a measure of a therapeutic effect that is considered reasonably likely to predict the clinical benefit of a drug, such as an effect on irreversible morbidity and mortality (IMM)." disney cars activity sheets The health department says Wisconsin’s case activity level has been “critically high” since Oct. 28; the state surged above the "critically high" threshold of 1,000 cases per 100,000 people at 1,311 cases, per thedata disney cars activity sheets Dr. Jason Knight, corresponding author and rheumatologist at Michigan Medicine said "half of the patients hospitalized with COVID-19 were positive for at least one of the autoantibodies, which was quite a surprise.” disney cars activity sheets Zients said the FDA is currently working with Johnson & Johnson to further investigate the issue, and that they will provide and update when the probe is complete. disney cars activity sheets

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