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This diminished effectiveness will likely crop up for other vaccines, too. blue baggy jeans outfit The B.1.351 variant is a strain of the coronavirus with eight distinctive mutations in the virus's spike protein, the structure that allows the virus to bind to and infect human cells, according to study by South African researchers posted to the preprint sitemedRxivin December 2020. blue baggy jeans outfit A team of researchers with Dr. Tracey A. Rouault, head of the NICHD arm on Human Iron Metabolism, uncovered the drug's potential by analyzing how the virus replicates in cells. The enzyme under study, RNA replicase, functions best with two so-called iron-sulfur clusters, whereas previous studies incorrectly pinned the structures as zinc-binding sites, according to the NIH. blue baggy jeans outfit "Given TEMPOL’s safety profile and the dosage considered therapeutic in our study, we are hopeful," Rouault added. "However, clinical studies are needed to determine if the drug is effective in patients, particularly early in the disease course when the virus begins to replicate." blue baggy jeans outfit

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