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Ph.D., CEO of San Diego-based Persephone Biosciences, is serving as chief investigator on a trial ultimately aiming to enroll up to 10,000 ethnically diverse participants nationwide for a study called"VOICES." joggers with side stripe “Many biological pathways signal the body to feel pain. One is through a protein named vascular endothelial growth factor-A (VEGF-A), which plays an essential role in blood vessel growth but also has been linked to diseases such as cancer, rheumatoid arthritis and, most recently, COVID-19,” the release reads. “Like a key in a lock, when VEGF-A binds to the receptor neuropilin, it initiates a cascade of events resulting in the hyperexcitability of neurons, which leads to pain.” joggers with side stripe Toxicology testing found a markedly elevated mast cell tryptase level - an increase in a released enzyme - in the blood in keeping with anaphylactic shock. joggers with side stripe “The spike protein completely reversed the VEGF-induced pain signaling,” said Khanna. “It didn’t matter if we used very high doses of spike or extremely low doses – it reversed the pain completely.” (iStock) joggers with side stripe

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